Infantry Suppression, also known as Suppression, is an instinctive defensive tactic used by human infantry when they come under enemy fire. Like "self-preservation", suppression happens when infantry go prone and move slower to protect themselves from taking too much damage. With this, their defensive and evasive abilities are increased, but their movement speed is dramatically slowed.

Generally, the more powerful the weapon attacking the infantry, the easier it is to suppress them.

Certain symbolic Black Hand units, such as Confessor Cabals and Purifiers automatically induce suppression for nearby enemies. The Voice of Kane also does the same.

Marked of Kane cyborg infantry such as The Awakened and The Enlightened are immune to suppression.

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