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San Diego is a coastal Southern California city located in the southwestern corner of the continental United States. It is the county seat of San Diego County and is the economic center of the San Diego–Carlsbad–San Marcos metropolitan area. It is located in the US West Coast Blue Zone.
In the opening stages of the Third Tiberium War, GDI commander Michael McNeil and the 22nd Infantry Division conducted an operation against Nod and their occupation of the San Diego naval base (the former HQ for the US Pacific Fleet), in the process procuring several T7 Tiberium-powered weapons.